Fundamentals of Intracellular Calcium by Anthony K. Campbell
Author:Anthony K. Campbell
Language: eng
Format: epub
Published: 2017-08-31T15:00:00+00:00
Box 7.1 Physiological cell events triggered by intracellular Ca2+.
Cell excitability, e.g. nerves, bioluminescence.
Cell movement, e.g. muscle contraction, chemotaxis in inflammation.
Membrane fusion, e.g. endo- and exo-crine secretion, phagocytosis, endocytosis.
Cell division and development, e.g. fertilisation, cell cycle, differentiation.
Senses, e.g. vision, taste, hearing.
There are thus five key questions that we need to answer:
How is the Ca2+ signal generated?
What is the intracellular Ca2+ target?
How does the target trigger the cell event?
How does the cell return to rest?
What is the role of Ca2+ in generating the energy required for the event via the MgATP/MgADP + phosphate reaction?
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